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David Ladrón de Guevara H. Paolo Catalán V. Claudia Hernández M. Juan Pablo Zhindon P.

Abstract

Aim: To establish the diagnostic accuracy of PET/CT in study of solid lung nodule (LN) using SUVmax index. Method: We revised PET/CT data base, selecting those scans asked to evaluate a solid LN. Only confirmed malign o benign LN were included. Subsolid LN, lung masses (> 3 cm), and known or suspected lung metastases were excluded. SUVmax was measured in each LN, and best cutoff for malignant and benign lesion was calculated. Results: Of the whole group of 140 LN, 60% were confirmed as malignant, and 40% as benign (100% and 59,6% of histological confirmation, respectively). SUVmax ? 1,0 showed sensibility of 98,8%, negative predictive value (NPV) of 96,2%, and negative likelihood ratio (LR –) of 0,027. SUVmax ? 2,5 was not able to guarantee reasonably benign nature of LN, showing NPV of 69,4% and LR – of 0,295. SUVmax > 2,5 and > 5,0 was associated to malign lesion in 83% and 93% of cases, respectively (LR + of 3,333 and 8,889). Conclusion: PET/CT shows high accuracy estimating the nature of solid LN. SUVmax ? 1,0 is highly predictive of benignity, and SUVmax ? 2,5 is highly predictive of malignancy. SUVmax values between 1,0 and 2,5 were not able to characterize efficiently LN.

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Ladrón de Guevara H., D., Catalán V., P., Hernández M., C., & Zhindon P., J. P. (2019). Value of Semiquantitative PET/CT (SUVmax) in study of solid lung nodule. Revista Chilena De Enfermedades Respiratorias, 35(2), 116–123. Retrieved from https://revchilenfermrespir.cl/index.php/RChER/article/view/822