Estrategia terapéutica para prevenir la remodelación de las vías aéreas

Abstract

Airways remodeling in asthma results in an increased thickness of airways walls, which in turns explains its association to an incomplete reversibility of airflow obstruction. In asthma has been observed that airways inflammation is an important contributor to both airways remodeling and irreversibility of airways obstruction. Epidemiological evidences that support the existance of airways remodeling in asthmatics are reviewed. As it was showed by the START study, inhaled steroid therapy to prevent airways remodeling in asthma should be iniciated at an early phase of the disease. Global iniciative for asthma -GINA- has proposed an early intervention in asthma with inhaled corticosteroids to prevent airways remodeling and its functional effects