Aumento del umbral tusígeno en sujetos sanos con el uso de Levodropropizina

Abstract

A randomized, prospective, double blind and placebo controlled study was designed to evaluate in 20 non smoker healthy adult volunteers the reproducibility and modification of cough threshold (CT) induced by capsaicin after placebo and Levodropropizine (a new synthetic drug). Adult volonteers of both sexes, mean age 34.9 years old (range: 18-57 years), inhaled increasing concentrations of capsaicin to determine the basal CT: log concentration of capsaicin that induced at least two consecutive coughs. The basal CT was 2.240 µM (± 0.060 SE), without differences by sex or age (p: ns), In 11 out of 18 subjects the CT increased from 2.358 (± 0,044 SE) on placebo to 2.469 µM (± 0.057) after Levodropropizine (p = 0.01). Two subjects were excluded due to intercurrent disease, not related to the study. No significant adverse reactions were reported during the study. Conclusion: Capsaicin induced reproducible controlled cough in 20 healthy volunteers and Levodropropizine given orally increased the cough threshold